index

import Pkg
Pkg.activate("..")

  Activating project at `~/run/_work/PumasTutorials.jl/PumasTutorials.jl/tutorials`

1 Attribution

The examples in this section are taken with permission from the Society of Pharmacometrics and Health Analytics who recently published a repository of models based on the excellent textbook on PKPD modeling by Gabrielson and Weiner.

A copy of this book can be ordered from Dipublish.com

PKPDDataAnalysisBook

All work is attributed to the contributed efforts of Sophas members. To know more and participate in further activities, read their release blog post

2 Table of Contents

• PK1 - One-compartment intravenous bolus dosing

• PK2 - One-compartment oral dosing

• PK3 - One-compartment 1^st and 0-order input

• PK4 - One-compartment oral dosing (part 1 & 2)

• PK4 - One-compartment oral dosing (part 3 & 4)

• PK5 - One-compartment intravenous plasma/urine I

• PK6 - One-compartment intravenous plasma/urine II

• PK8 - Two-compartment distribution models

• PK9 - Modeling of fraction absorbed and nonlinear bioavailability across the liver: Simultaneously fitting intravenous and oral data

• PK10 - Simultaneous fitting of IV/PO data

• PK12 - Intravenous and oral dosing

• PK13 - Bolus plus constant rate infusion

• PK14 - Multi-compartment model oral dosing

• PK15 - Toxicokinetics

• PK16 - Two-compartment intravenous plasma/urine

• PK17 - Nonlinear kinetics - Capacity I

• PK18 - Capacity II - Ethanol kinetics

• PK19 - Capacity III - Metabolite kinetics

• PK20 - Capacity IV - Nonlinear kinetics

• PK21 - Nonlinear kinetics - Heteroinduction

• PK22 - Nonlinear kinetics - Autoinduction

• PK24 - Nonlinear kinetics - Flow II

• PK26 - Modeling of antibody kinetics after i.v. doses to man

• PK27 - Target mediated drug disposition

• PK28 - Allometry - Elementary Dedrick plot

• PK30 - Turnover I - Sc dosing of hormone

• PK31 - Turnover II - Intra-venous dosing of hormone

• PK32 - Turnover III - Nonlinear disposition

• PK33 - Transdermal input and kinetics

• PK34 - Reversible metabolism

• PK38 - In vitro/in vivo extrapolation II

• PK39 - Two-compartment data - Experimental design issues

• PK40 - Enterohepatic recirculation

• PK41 - Multiple intravenous infusions - NCA versus regression

• PK42 - Saturable absorption via transporters

• PK43 - Multiple absorption routes

• PK45 - Reversible metabolism of drug A and its metabolite drug B

• PK46 - Long infusion and short half-life

• PK47 - Plasma protein binding modeling

• PK48 - One-compartment Michaelis-Menten kinetics - Drug and metabolite in urine

• PK49 - Turnover IV - Factor II data in healthy volunteers

• PK50 - Analysis of multiple subjects concentration and response-time profiles

• PK51 - Multi-compartment drug/metabolite

• PK52 - Simulated impact of disease on r-hSOD kinetics

• PK53 - Linear antibody kinetics